4.7 T/33 cm Agilent VNMRS

preclinical mri/s – "4.7 T"

4.7 T/33 cm Agilent VNMRS

MBI, AMRIS Facility, LG-123C

4.7 t mri


  • Oxford 4.7 T 33 cm actively-shielded horizontal magnet
  • Agilent VNMRS console/VnmrJ3.1 with 4 1H /1 BB transmitter and 4 channel receivers
  • IECO GPA-400-750, 400A/750V peak 3-Axis MRI Gradient Amplifier

Gradient Coils

  • Oxford 330/225 – bore size 225mm, Gmax = 65 mT/m with 700 µs risetime
  • RRI BFG-200/115-S14 – bore size 115mm, Gmax = 670mT/m (@300A) with 120us risetime

RF Coils

  • 1H – 200MHz, solenoid linear 1.2cm
  • 1H – 200MHz, quadrature birdcage 3.3/6.2cm (Coil 301)
  • 1H – 200MHz, quadrature birdcage 5.0/8.8cm (Coil 302)
  • 1H – 200MHz, quadrature birdcage 9.5/14cm
  • 1H – 200MHz, quadrature birdcage TX-only, 8.8/11.6cm (Coil307)/ 3.0×3.5cm quadrature RX-only coil,
  • 1H – 200MHz, Varian quadrature birdcage 3.8/10.8cm
  • 1H – 200MHz, Varian quadrature birdcage 6.3/10.8cm
  • 1H – 200MHz, quadrature surface coil 2.0×3.0cm
  • 1H – 200MHz, quadrature surface coil 1.5×2.9cm
  • 1H – 200MHz, Four element surface array – each element 3.0cm x 3.0cm
  • 31P – 81MHz, 1.5cm diameter
  • 13C – 50MHz, 1.5cm diameter

We have recently implemented dissolution DNP technology in the AMRIS facility. Our system utilizes a 5 T magnet in which samples are cooled to <1.1 K. With microwave irradiation, we achieve 70% polarization of 13C nuclei in the polarizer; this translates to a >14,000 gain in SNR on dissolution and injection into our 4.7T MRI/S scanner. The custom design of the polarizer enables the use of dissolution DNP to study metabolic flux in vivo using a variety of NMR –active nuclei as well as the study of fundamental mechanisms of polarization enhancement. This polarizer is available to external users through the MagLab.