Facility Highlights
MAGLAB SCIENCE HIGHLIGHT – MAy 2023
Anionic Phospholipids Control Mechanisms of GPCR-G Protein Recognition
Drugs, hormones, and neurotransmitters stimulate the formation of signaling complexes in cells. The formation of these protein complexes is facilitated by the presence of specific endogenous lipid molecules. NMR spectroscopy can observe different three-dimensional conformations of protein receptors and determine how drugs and lipids impact these conformations that correlate with changes in receptor function. State-of-the-art NMR instrumentation at the MagLab’s AMRIS Facility is uniquely suited for precise measurements of lipid compositions and simultaneous investigation of receptor protein conformations because it enables the visualization of multiple different nuclei of importance to these studies, in particular 1H, 19F, and 31P.
Previous highlights can be found in our News Archive.
About Us
AMRIS is an NMR/MRI auxiliary located at the McKnight Brain Institute of the University of Florida that supports UF research groups and operates as an international user facility for the NSF-funded National High Magnetic Field Laboratory (NHMFL). The AMRIS Facility receives funding support through the NSF, NIH, and the State of Florida.
Access for users external to UF and technology development time are available through the NHMFL Users Program. Please review our reservation and billing policies prior to making your reservations, as this includes our policy regarding cancellations. AMRIS magnet time should be requested by the 15th of the month prior to the reservation. Reservations must be made using our online request form.
Please remember that ALL publications containing data collected at AMRIS must acknowledge the National Science Foundation Cooperative Agreement. Also, several instruments were purchased with NIH equipment funds; data collected using these instruments should acknowledge the appropriate NIH grants. Sample text for facility and instrumentation acknowledgment is provided.
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Whether you will be coming to AMRIS in person or making arrangements with a staff member to submit your samples for remote analysis, you must request the instrument time through our online request form.
The University of Florida campus is following UFHealth and CDC guidance to prevent the spread of SARS-CoV-2, aka COVID-19. We have developed our covid-safety SOPs to maintain the cleanliness of commonly touched objects and surfaces, but please stay home if you are sick or if you recently (last 14 days) visited an area where COVID-19 cases are spiking.
As a reminder, we continue to enforce our standard cancellation policy for billing purposes, but we do ask that you notify us as soon as possible whenever reservations must be cancelled. If you need to cancel your reservations or postpone studies, you may simply indicate COVID-19 as the reason when you submit the cancellation (no further details are needed).
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